What is SYFOVRE^®?

SYFOVRE is the first FDA-approved treatment for GA.

Slowing lesion growth can delay the progression of GA

SYFOVRE was proven to slow the growth of GA lesions

SYFOVRE was studied in 2 clinical trials of over 1200 people with GA. In both trials, lesion growth slowed down for patients who received SYFOVRE versus those who did not.

Trial 1

After 2 years, compared to those who did not receive SYFOVRE,
SYFOVRE slowed lesion growth by

22 %

when taken
monthly
(n=202)

18 %

when taken
every other month
(n=205)

Trial 2

After 2 years, compared to those who did not receive SYFOVRE,
SYFOVRE slowed lesion growth by

18 %

when taken
monthly
(n=201)

17 %

when taken
every other month
(n=201)

It’s important to stay on treatment with SYFOVRE as recommended by your retina specialist to see continued results.

GA cannot be cured, and the damage cannot be reversed. However, slowing down lesion growth can help delay the progression of GA.

Starting SYFOVRE is an important first step—staying on treatment as recommended by your retina specialist is just as important.

Want to stay up to date on SYFOVRE? Join our email list.

The resources on this website are meant to be informational only and are not intended to replace medical advice. Always talk to your healthcare provider about any medical decisions, including how to manage geographic atrophy (GA) and how it affects your everyday life.

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How SYFOVRE Works

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about SYFOVRE^® (pegcetacoplan injection)?

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat geographic atrophy (GA), the dry advanced form of age-related macular degeneration (AMD).

What is the most important information I should know about SYFOVRE^® (pegcetacoplan injection)?

Who should NOT receive SYFOVRE?

Do not receive SYFOVRE if you:

have an infection in or around your eye
have active swelling in or around your eye that may include pain and redness

SYFOVRE can cause serious side effects:

Eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment)
- Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light
Risk of developing wet age-related macular degeneration (AMD). You should be monitored for signs of wet AMD and you should report any symptoms (eg, visual distortion, deterioration in vision, black spots, loss of central vision) to your healthcare provider
Episodes of eye inflammation. You should report any symptoms (eg, pain or discomfort, redness, swelling, or sensitivity to light, small specks floating in your vision, changes in vision) to your healthcare provider
Increase in eye pressure within minutes of the injection. Your healthcare provider will monitor this after each injection

Before receiving SYFOVRE:

Tell your healthcare provider if any of the following applies to you:
- If you have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks
- If you have high pressure in the eye or if you have glaucoma

Tell your healthcare provider about all of your medical conditions, including
- If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

What should I avoid while receiving SYFOVRE?

After an injection or an eye exam, your eyesight may temporarily be impaired. Do not drive or use machinery until your vision recovers

What are the most common side effects of SYFOVRE?

Eye discomfort
Wet age-related macular degeneration
Small specks floating in vision
Blood in the white of the eye

These are not all the possible side effects of SYFOVRE. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat GA, the dry advanced form of AMD.

Please see full Prescribing Information for more information.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about SYFOVRE^® (pegcetacoplan injection)?

Who should NOT receive SYFOVRE?

Do not receive SYFOVRE if you:

have an infection in or around your eye
have active swelling in or around your eye that may include pain and redness

SYFOVRE can cause serious side effects:

Eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment)
- Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light
Risk of developing wet age-related macular degeneration (AMD). You should be monitored for signs of wet AMD and you should report any symptoms (eg, visual distortion, deterioration in vision, black spots, loss of central vision) to your healthcare provider
Episodes of eye inflammation. You should report any symptoms (eg, pain or discomfort, redness, swelling, or sensitivity to light, small specks floating in your vision, changes in vision) to your healthcare provider
Increase in eye pressure within minutes of the injection. Your healthcare provider will monitor this after each injection

Before receiving SYFOVRE:

Tell your healthcare provider if any of the following applies to you:
- If you have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks
- If you have high pressure in the eye or if you have glaucoma

Tell your healthcare provider about all of your medical conditions, including
- If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

What should I avoid while receiving SYFOVRE?

After an injection or an eye exam, your eyesight may temporarily be impaired. Do not drive or use machinery until your vision recovers

What are the most common side effects of SYFOVRE?

Eye discomfort
Wet age-related macular degeneration
Small specks floating in vision
Blood in the white of the eye

These are not all the possible side effects of SYFOVRE. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat GA, the dry advanced form of AMD.

Please see full Prescribing Information for more information.