About SYFOVRE® (pegcetacoplan injection)

Largest and longest studies of any FDA-approved treatment for GA

Slows GA progression with an increasing effect over time. The greatest difference was seen during the last 6 months

Proven to slow GA lesion growth

Only SYFOVRE slows GA in as few as 6 doses per year*

*Your doctor will decide how often you receive SYFOVRE (once every 25-60 days).

SYFOVRE was studied in 2 clinical studies with over 1200 people.

Compared to those untreated, after 2 years SYFOVRE slowed GA lesion growth by 17% (every other month) to 22% (monthly). After 2 years, SYFOVRE slowed GA progression by 18% and 22% (monthly) (n=402) and by 17% and 18% (every other month) (n=406) compared to those untreated.

*After 2 years, SYFOVRE slowed GA progression by 18% and 22% (monthly, 403 patients) or by 17% and 18% (every other month, 406 patients) compared to those untreated.

Getting on treatment can make a difference in slowing GA progression, so if you've been diagnosed, don't wait. Talk to your doctor and take action now. — Rob, real SYFOVRE patient

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How SYFOVRE Works

The resources on this website are meant to be informational only and are not intended to replace medical advice. Always talk to your healthcare provider about any medical decisions, including how to manage geographic atrophy (GA) and how it affects your everyday life.

IMPORTANT SAFETY INFORMATION

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat geographic atrophy (GA), the dry advanced form of age-related macular degeneration (AMD).

Who should NOT receive SYFOVRE^® (pegcetacoplan injection)?

Do not receive SYFOVRE if you have an infection or active swelling in or around your eye that may include pain and redness, or are allergic to pegcetacoplan or any ingredients in SYFOVRE. SYFOVRE can cause serious allergic reactions such as trouble breathing, tongue, face, lips, or mouth swelling, rashes, and hives.

Who should NOT receive SYFOVRE^® (pegcetacoplan injection)?

SYFOVRE can cause serious side effects:

Eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment)
- Call your healthcare provider right away if you have eye redness, light sensitivity, eye pain, or any change in vision including blurred, wavy/distorted vision, small specks floating in your vision, or flashing lights
Severe inflammation of vessels in the retina which may result in severe vision loss. Call your healthcare provider right away if you have eye redness, light sensitivity, eye pain, or any change in vision including blurred, wavy/distorted vision, or flashing lights
Risk of developing wet AMD. You should be monitored for signs of wet AMD and you should report if you have any change in vision including blurred, wavy/distorted vision, black spots, or loss of central vision to your healthcare provider
Episodes of eye inflammation. You should report any symptoms including eye redness, light sensitivity, eye pain, small specks floating in your vision, or any changes in vision to your healthcare provider
Increase in eye pressure within minutes of the injection. Your healthcare provider will monitor this after each injection

Before receiving SYFOVRE:

Tell your healthcare provider if any of the following applies to you:
- If you have a history of seeing flashes of light or small specks floating in your vision and notice a sudden increase of size and number of these specks
- If you have high pressure in the eye or glaucoma

Tell your healthcare provider about all of your medical conditions, including
- If you are, or think you are pregnant, breastfeeding, or are planning to have a baby, ask your doctor for advice before taking this medicine

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

What should I avoid while receiving SYFOVRE?

After an injection or an eye exam, your eyesight may temporarily be impaired. Do not drive or use machinery until your vision recovers

What are the most common side effects of SYFOVRE?

Eye discomfort
Wet age-related macular degeneration
Small specks floating in vision
Blood in the white of the eye

These are not all the possible side effects of SYFOVRE. Tell your healthcare provider about any side effect that bothers you or does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat GA, the dry advanced form of AMD.

Please see full Prescribing Information for more information.

IMPORTANT SAFETY INFORMATION

Who should NOT receive SYFOVRE^® (pegcetacoplan injection)?

SYFOVRE can cause serious side effects:

Eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment)
- Call your healthcare provider right away if you have eye redness, light sensitivity, eye pain, or any change in vision including blurred, wavy/distorted vision, small specks floating in your vision, or flashing lights
Severe inflammation of vessels in the retina which may result in severe vision loss. Call your healthcare provider right away if you have eye redness, light sensitivity, eye pain, or any change in vision including blurred, wavy/distorted vision, or flashing lights
Risk of developing wet AMD. You should be monitored for signs of wet AMD and you should report if you have any change in vision including blurred, wavy/distorted vision, black spots, or loss of central vision to your healthcare provider
Episodes of eye inflammation. You should report any symptoms including eye redness, light sensitivity, eye pain, small specks floating in your vision, or any changes in vision to your healthcare provider
Increase in eye pressure within minutes of the injection. Your healthcare provider will monitor this after each injection

Before receiving SYFOVRE:

Tell your healthcare provider if any of the following applies to you:
- If you have a history of seeing flashes of light or small specks floating in your vision and notice a sudden increase of size and number of these specks
- If you have high pressure in the eye or glaucoma

Tell your healthcare provider about all of your medical conditions, including
- If you are, or think you are pregnant, breastfeeding, or are planning to have a baby, ask your doctor for advice before taking this medicine

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

What should I avoid while receiving SYFOVRE?

After an injection or an eye exam, your eyesight may temporarily be impaired. Do not drive or use machinery until your vision recovers

What are the most common side effects of SYFOVRE?

Eye discomfort
Wet age-related macular degeneration
Small specks floating in vision
Blood in the white of the eye

These are not all the possible side effects of SYFOVRE. Tell your healthcare provider about any side effect that bothers you or does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat GA, the dry advanced form of AMD.

Please see full Prescribing Information for more information.

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Take action to slow GA with SYFOVRE.

What is SYFOVRE^®?