Frequently Asked Questions

Questions about SYFOVRE®

Starting SYFOVRE

If you have geographic atrophy (GA), talk to your retina specialist to see if SYFOVRE is right for you. They can tell you more about how to get started.

SYFOVRE is the first FDA-approved treatment for GA. SYFOVRE has been clinically proven to slow the growth of GA lesions in 2 clinical trials.

It’s important to know that GA cannot be cured, and the damage cannot be reversed. However, slowing down lesion growth can help delay the progression of GA.

SYFOVRE is not a one-time treatment; rather, SYFOVRE is available once every 25 to 60 days depending on your retina specialist’s recommendation.

Talk to your retina specialist about which treatment schedule may be right for you.

Stay on SYFOVRE as long as your retina specialist recommends so it can continue to delay lesion growth.

SYFOVRE is an eye injection given in-office by a retina specialist who will numb your eye beforehand.

During your appointment, your retina specialist will prepare you to receive SYFOVRE by numbing your eye. They will then inject SYFOVRE. After each injection or eye exam, your vision may be impaired; do not drive or use machinery until your vision recovers.

What is the most important information to know about SYFOVRE?

Do not receive SYFOVRE if you have an infection, or active swelling in or around your eye that may include pain and redness.

SYFOVRE can cause serious side effects:

  • Injections like the one for SYFOVRE can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment)
  • Call your healthcare provider right away if you have eye redness, light sensitivity, eye pain, or any change in vision including blurred, wavy/distorted vision, small specks floating in your vision, or flashing lights
  • Following SYFOVRE administration, patients can experience severe inflammation of vessels in the retina which may result in severe vision loss. Call your healthcare provider right away if you have eye redness, light sensitivity, eye pain, or any change in vision including blurred, wavy/distorted vision, or flashing lights
  • Following SYFOVRE administration, patients are at risk for developing wet age-related macular degeneration (AMD). You should be monitored for signs of wet AMD and you should report if you have any change in vision including blurred, wavy/distorted vision, black spots, or loss of central vision to your healthcare provider
  • SYFOVRE may cause episodes of eye inflammation. You should report any symptoms including eye redness, light sensitivity, eye pain, small specks floating in your vision, or any changes in vision to your healthcare provider
  • SYFOVRE may cause an increase in eye pressure within minutes of the injection. Your healthcare provider will monitor this after each injection

The most common side effects with SYFOVRE are:

  • Eye discomfort
  • Wet age-related macular degeneration
  • Small specks floating in vision
  • Blood in the white of the eye

These are not all possible side effects of SYFOVRE. Tell your healthcare provider about any side effect that bothers you or that does not go away.

After a SYFOVRE injection or an eye exam, your eyesight may temporarily be impaired. Do not drive or use machinery until your vision recovers.

Please plan to have a ride to and from your appointment.

SYFOVRE appointments

It’s a good plan to read SYFOVRE materials you receive from your eye doctor. If you did not receive any materials, please visit the Getting Started on SYFOVRE page for more information.

You can also stay informed about SYFOVRE by signing up for emails here.
If you still have questions, write them down to ask your retina specialist during your appointment.

An Amsler grid is a tool you can use to help you keep track of your vision between appointments. If you notice any changes in your vision, talk to your retina specialist. Click here to download the Amsler Grid.

Your vision may be impaired after receiving a SYFOVRE injection or after an eye exam so you may want to have someone with you to drive you home.

If an injection is missed, call your retina specialist. They will determine when you should receive your next injection.

Want to stay up to date on SYFOVRE? Join our email list.

The resources on this website are meant to be informational only and are not intended to replace medical advice. Always talk to your healthcare provider about any medical decisions, including how to manage geographic atrophy (GA) and how it affects your everyday life.


IMPORTANT SAFETY INFORMATION

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat geographic atrophy (GA), the dry advanced form of age-related macular degeneration (AMD).

Who should NOT receive SYFOVRE® (pegcetacoplan injection)?

Do not receive SYFOVRE if you have an infection, or active swelling in or around your eye that may include pain and redness

Who should NOT receive SYFOVRE® (pegcetacoplan injection)?

Do not receive SYFOVRE if you have an infection, or active swelling in or around your eye that may include pain and redness

SYFOVRE can cause serious side effects:

  • Eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment)
    • Call your healthcare provider right away if you have eye redness, light sensitivity, eye pain, or any change in vision including blurred, wavy/distorted vision, small specks floating in your vision, or flashing lights
  • Severe inflammation of vessels in the retina which may result in severe vision loss. Call your healthcare provider right away if you have eye redness, light sensitivity, eye pain, or any change in vision including blurred, wavy/distorted vision, or flashing lights
  • Risk of developing wet AMD. You should be monitored for signs of wet AMD and you should report if you have any change in vision including blurred, wavy/distorted vision, black spots, or loss of central vision to your healthcare provider
  • Episodes of eye inflammation. You should report any symptoms including eye redness, light sensitivity, eye pain, small specks floating in your vision, or any changes in vision to your healthcare provider
  • Increase in eye pressure within minutes of the injection. Your healthcare provider will monitor this after each injection

Before receiving SYFOVRE:

  • Tell your healthcare provider if any of the following applies to you:
    • If you have a history of seeing flashes of light or small specks floating in your vision and notice a sudden increase of size and number of these specks
    • If you have high pressure in the eye or glaucoma
  • Tell your healthcare provider about all of your medical conditions, including
    • If you are, or think you are pregnant, breastfeeding, or are planning to have a baby, ask your doctor for advice before taking this medicine
  • Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

What should I avoid while receiving SYFOVRE?

  • After an injection or an eye exam, your eyesight may temporarily be impaired. Do not drive or use machinery until your vision recovers

What are the most common side effects of SYFOVRE?

  • Eye discomfort
  • Wet age-related macular degeneration
  • Small specks floating in vision
  • Blood in the white of the eye

These are not all the possible side effects of SYFOVRE. Tell your healthcare provider about any side effect that bothers you or does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat GA, the dry advanced form of AMD.

Please see full Prescribing Information for more information.

IMPORTANT SAFETY INFORMATION

Who should NOT receive SYFOVRE® (pegcetacoplan injection)?

Do not receive SYFOVRE if you have an infection, or active swelling in or around your eye that may include pain and redness

SYFOVRE can cause serious side effects:

  • Eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment)
    • Call your healthcare provider right away if you have eye redness, light sensitivity, eye pain, or any change in vision including blurred, wavy/distorted vision, small specks floating in your vision, or flashing lights
  • Severe inflammation of vessels in the retina which may result in severe vision loss. Call your healthcare provider right away if you have eye redness, light sensitivity, eye pain, or any change in vision including blurred, wavy/distorted vision, or flashing lights
  • Risk of developing wet AMD. You should be monitored for signs of wet AMD and you should report if you have any change in vision including blurred, wavy/distorted vision, black spots, or loss of central vision to your healthcare provider
  • Episodes of eye inflammation. You should report any symptoms including eye redness, light sensitivity, eye pain, small specks floating in your vision, or any changes in vision to your healthcare provider
  • Increase in eye pressure within minutes of the injection. Your healthcare provider will monitor this after each injection

Before receiving SYFOVRE:

  • Tell your healthcare provider if any of the following applies to you:
    • If you have a history of seeing flashes of light or small specks floating in your vision and notice a sudden increase of size and number of these specks
    • If you have high pressure in the eye or glaucoma
  • Tell your healthcare provider about all of your medical conditions, including
    • If you are, or think you are pregnant, breastfeeding, or are planning to have a baby, ask your doctor for advice before taking this medicine
  • Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

What should I avoid while receiving SYFOVRE?

  • After an injection or an eye exam, your eyesight may temporarily be impaired. Do not drive or use machinery until your vision recovers

What are the most common side effects of SYFOVRE?

  • Eye discomfort
  • Wet age-related macular degeneration
  • Small specks floating in vision
  • Blood in the white of the eye

These are not all the possible side effects of SYFOVRE. Tell your healthcare provider about any side effect that bothers you or does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat GA, the dry advanced form of AMD.

Please see full Prescribing Information for more information.