How is age-related macular degeneration (AMD) connected to
Geographic Atrophy GA ?

AMD can progress to GA, Wet AMD, or both

AMD

can progress to either (or both)

GA

Eyes with GA can also develop wet AMD

Wet AMD^*

Eyes with wet AMD can also develop GA

SYFOVRE is the first FDA-approved treatment for GA. It is not approved to treat wet AMD.

Click on the tabs below to learn more about each eye disease.

AMD is an eye disease primarily found in people over the age of 50
Although symptoms may be mild, it can lead to reduced vision or blurriness
Even small vision changes can mean that AMD may be progressing to GA, wet AMD, or both

GA is the dry, advanced form of AMD
It happens when patches of damaged cells, called lesions, permanently damage the retina
GA gets worse over time and is irreversible

Click here to learn how GA progresses

Wet AMD happens when new blood vessels grow and leak into the macula
It causes bleeding, scarring, and sudden vision changes
GA and wet AMD share similar symptoms

Talk to your eye doctor today if you notice any changes in your vision.

*SYFOVRE is not approved to treat wet AMD.

Before SYFOVRE, living with GA meant never being able to slow down disease progression.

Ask your eye doctor about SYFOVRE, the first FDA‑approved treatment for GA.

Want to stay up to date on SYFOVRE? Join our email list.

The resources on this website are meant to be informational only and are not intended to replace medical advice. Always talk to your healthcare provider about any medical decisions, including how to manage geographic atrophy (GA) and how it affects your everyday life.

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GA Symptoms

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What is SYFOVRE?

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about SYFOVRE^® (pegcetacoplan injection)?

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat geographic atrophy (GA), the dry advanced form of age-related macular degeneration (AMD).

What is the most important information I should know about SYFOVRE^® (pegcetacoplan injection)?

Who should NOT receive SYFOVRE?

Do not receive SYFOVRE if you:

have an infection in or around your eye
have active swelling in or around your eye that may include pain and redness

SYFOVRE can cause serious side effects:

Eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment)
- Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light
Risk of developing wet age-related macular degeneration (AMD). You should be monitored for signs of wet AMD and you should report any symptoms (eg, visual distortion, deterioration in vision, black spots, loss of central vision) to your healthcare provider
Episodes of eye inflammation. You should report any symptoms (eg, pain or discomfort, redness, swelling, or sensitivity to light, small specks floating in your vision, changes in vision) to your healthcare provider
Increase in eye pressure within minutes of the injection. Your healthcare provider will monitor this after each injection

Before receiving SYFOVRE:

Tell your healthcare provider if any of the following applies to you:
- If you have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks
- If you have high pressure in the eye or if you have glaucoma

Tell your healthcare provider about all of your medical conditions, including
- If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

What should I avoid while receiving SYFOVRE?

After an injection or an eye exam, your eyesight may temporarily be impaired. Do not drive or use machinery until your vision recovers

What are the most common side effects of SYFOVRE?

Eye discomfort
Wet age-related macular degeneration
Small specks floating in vision
Blood in the white of the eye

These are not all the possible side effects of SYFOVRE. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat GA, the dry advanced form of AMD.

Please see full Prescribing Information for more information.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about SYFOVRE^® (pegcetacoplan injection)?

Who should NOT receive SYFOVRE?

Do not receive SYFOVRE if you:

have an infection in or around your eye
have active swelling in or around your eye that may include pain and redness

SYFOVRE can cause serious side effects:

Eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment)
- Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light
Risk of developing wet age-related macular degeneration (AMD). You should be monitored for signs of wet AMD and you should report any symptoms (eg, visual distortion, deterioration in vision, black spots, loss of central vision) to your healthcare provider
Episodes of eye inflammation. You should report any symptoms (eg, pain or discomfort, redness, swelling, or sensitivity to light, small specks floating in your vision, changes in vision) to your healthcare provider
Increase in eye pressure within minutes of the injection. Your healthcare provider will monitor this after each injection

Before receiving SYFOVRE:

Tell your healthcare provider if any of the following applies to you:
- If you have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks
- If you have high pressure in the eye or if you have glaucoma

Tell your healthcare provider about all of your medical conditions, including
- If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

What should I avoid while receiving SYFOVRE?

After an injection or an eye exam, your eyesight may temporarily be impaired. Do not drive or use machinery until your vision recovers

What are the most common side effects of SYFOVRE?

Eye discomfort
Wet age-related macular degeneration
Small specks floating in vision
Blood in the white of the eye

These are not all the possible side effects of SYFOVRE. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat GA, the dry advanced form of AMD.

Please see full Prescribing Information for more information.