What is Geographic
Atrophy GA ?

GA is a relentless and irreversible eye disease that is the dry, advanced form of age-related macular degeneration (AMD).

How GA Progresses in the Eye*

Side view of normal eye

Retina

Back of the eye with GA lesions

Lesions

GA lesion progression

Macula

Continued GA lesion progression

Macula

*Images are for illustrative purposes only. Drawing is not a true cross-section.

GA can worsen over time and lead to permanent and irreversible vision loss that cannot be corrected with eyeglasses or surgery.

It’s important to slow lesion growth to delay the progression of GA

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The resources on this website are meant to be informational only and are not intended to replace medical advice. Always talk to your healthcare provider about any medical decisions, including how to manage geographic atrophy (GA) and how it affects your everyday life.

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IMPORTANT SAFETY INFORMATION

What is the most important information I should know about SYFOVRE® (pegcetacoplan injection)?

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat geographic atrophy (GA), the dry advanced form of age-related macular degeneration (AMD).

What is the most important information I should know about SYFOVRE® (pegcetacoplan injection)?

Who should NOT receive SYFOVRE?

Do not receive SYFOVRE if you:

  • have an infection in or around your eye
  • have active swelling in or around your eye that may include pain and redness

SYFOVRE can cause serious side effects:

  • Eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment)
    • Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light
  • Risk of developing wet age-related macular degeneration (AMD). You should be monitored for signs of wet AMD and you should report any symptoms (eg, visual distortion, deterioration in vision, black spots, loss of central vision) to your healthcare provider
  • Episodes of eye inflammation. You should report any symptoms (eg, pain or discomfort, redness, swelling, or sensitivity to light, small specks floating in your vision, changes in vision) to your healthcare provider
  • Increase in eye pressure within minutes of the injection. Your healthcare provider will monitor this after each injection

Before receiving SYFOVRE:

  • Tell your healthcare provider if any of the following applies to you:
    • If you have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks
    • If you have high pressure in the eye or if you have glaucoma
  • Tell your healthcare provider about all of your medical conditions, including
    • If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine
  • Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

What should I avoid while receiving SYFOVRE?

  • After an injection or an eye exam, your eyesight may temporarily be impaired. Do not drive or use machinery until your vision recovers

What are the most common side effects of SYFOVRE?

  • Eye discomfort
  • Wet age-related macular degeneration
  • Small specks floating in vision
  • Blood in the white of the eye

These are not all the possible side effects of SYFOVRE. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat GA, the dry advanced form of AMD.

Please see full Prescribing Information for more information.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about SYFOVRE® (pegcetacoplan injection)?

Who should NOT receive SYFOVRE?

Do not receive SYFOVRE if you:

  • have an infection in or around your eye
  • have active swelling in or around your eye that may include pain and redness

SYFOVRE can cause serious side effects:

  • Eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment)
    • Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light
  • Risk of developing wet age-related macular degeneration (AMD). You should be monitored for signs of wet AMD and you should report any symptoms (eg, visual distortion, deterioration in vision, black spots, loss of central vision) to your healthcare provider
  • Episodes of eye inflammation. You should report any symptoms (eg, pain or discomfort, redness, swelling, or sensitivity to light, small specks floating in your vision, changes in vision) to your healthcare provider
  • Increase in eye pressure within minutes of the injection. Your healthcare provider will monitor this after each injection

Before receiving SYFOVRE:

  • Tell your healthcare provider if any of the following applies to you:
    • If you have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks
    • If you have high pressure in the eye or if you have glaucoma
  • Tell your healthcare provider about all of your medical conditions, including
    • If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine
  • Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

What should I avoid while receiving SYFOVRE?

  • After an injection or an eye exam, your eyesight may temporarily be impaired. Do not drive or use machinery until your vision recovers

What are the most common side effects of SYFOVRE?

  • Eye discomfort
  • Wet age-related macular degeneration
  • Small specks floating in vision
  • Blood in the white of the eye

These are not all the possible side effects of SYFOVRE. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is SYFOVRE?

SYFOVRE is a prescription eye injection, used to treat GA, the dry advanced form of AMD.

Please see full Prescribing Information for more information.